Beilstein J. Nanotechnol.2014,5, 1357–1370, doi:10.3762/bjnano.5.149
–liquid exposure; dosimetry; lungcellsinvitro; silver nanoparticles; toxicity; Introduction
Silver possesses antiseptic and germicidal properties [1]. These effects are enhanced in combination with the possibilities of nanotechnology, when silver is manufactured as particles at the nanoscale. Defined
breaking of DNA strands and covalent DNA modifications [10]. Hence, Ag NPs have been shown to cause significant DNA damage in human lungcellsinvitro [25][27] suggesting a potential genotoxic mechanism. Despite this, the specific interaction of Ag NPs with cells still remains unclear.
Ag NPs released
ISDD model it was possible to compare dose effects in two distinct exposure scenarios.
Currently three different strategies are used to investigate possible effects of inhaled Ag NPs. Most commonly Ag NPs are applied in dispersion onto different lungcellsinvitro [22][30][37][50][51], animal models
PDF
Figure 1:
Scanning electron microscopic image (A) of Ag NPs deposited on a silicon wafer. The particle size d...
Beilstein J. Nanotechnol.2013,4, 933–940, doi:10.3762/bjnano.4.105
be able to cross the air-blood-barrier (ABB), towards circulation, and accumulate in secondary organs [16][17].
Some in vitro studies have demonstrated toxic effects of AgNP on lungcells: Invitro incubation of a rat alveolar macrophage cell line with AgNP induced a concentration- as well as a size
PDF
Figure 1:
Representative transmission (A) and scanning electron (B) images of PVP-coated AgNP.